主要承担的科研项目： | 1.湖北省自然基金青年项目，2022CFB885，基于小分子 2-甲氧基-6-乙酰基-7-甲基胡桃酮激活铁死亡抑制耐药非小细胞肺癌作用与机制研究，2022-10 至 2024-9,在研, 主持。 2.武汉知识创新专项曙光计划项目，2023020201020459，基于肿瘤细胞脂代谢的NQO1底物抗耐药肿瘤作用的分子机制研究，2023-06 至 2025-06，在研，主持。 3.湖北省教育厅科学研究计划指导性项目, B2021126, 2-甲氧基-6-乙酰基-7-甲基胡桃酮抗恶性脑胶质瘤的作用机制研究, 2021-01 至 2022-12,结题, 主持。 3. 澳门科学技术发展基金, 科研项目, 175/2017/A3 , 基于上皮-间质转化探讨中药之分子机制与治疗意义, 2018-05 至 2021-05,结题, 参与。 4. 澳门科学技术发展基金, 科研项目, 078/2016/A2, 基于程序性坏死探讨中药成分抗肿瘤之作用机制与治疗意义, 2017-03 至 2020-03,结题, 参与。 |
代表性论文与著作： | 1.Yu J, Zhong B, Zhao L, Hou Y, Ai N, Lu JJ, Ge W, Chen X. Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis, Drug resistance update, 2023.（二修DRU-D-22-00010R1） 2.Yu J, Zhong B, Zhao L, Hou Y, Wang X, Chen X. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors Necrostatin-1 (Nec-1) and 7-Cl-O-Nec-1 (Nec-1s) are potent inhibitors of NAD(P)H: Quinone oxidoreductase 1 (NQO1), Free Radical Biology and Medicine, 2021, 173: 64-69. 3.Yu J, Zhong B, Xiao Q, Du L, Hou Y, Sun HS, Lu JJ, Chen X. Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds. Pharmacology & Therapeutics. 2020 May 31:107593. 4.Yu J, Zhong B, Jin L, Hou Y, Ai N, Ge W, Li L, Liu S, Lu JJ, Chen X. 2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1). Free Radical Biology and Medicine. 2020 Mar 28;152:336-347. 5.Sun W, Yu J, Gao H, Wu X, Wang S, Hou Y, Lu JJ, Chen X. Inhibition of Lung Cancer by 2-Methoxy-6-Acetyl-7-Methyljuglone Through Induction of Necroptosis by Targeting Receptor-Interacting Protein 1. Antioxidants & Redox Signaling. 2019 Jul 10;31(2):93-108. co-first author. 6.Yu J, Gao H, Wu C, Xu QM, Lu JJ, Chen X. Diethyl Blechnic, a Novel Natural Product Isolated from Salvia miltiorrhiza Bunge, Inhibits Doxorubicin-Induced Apoptosis by Inhibiting ROS and Activating JNK1/2. International Journal of Molecular Sciences. 2018 Jun 19;19(6). 7.Yu J, Wang C, Kong Q, Wu X, Lu JJ, Chen X. Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine. 2018 Feb 1;40:125-139. 8.Li J, Yu J, Ma H, Yang N, Li L, Zheng DD, Wu MX, Zhao ZL, Qi HY. Intranasal Pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, Confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling Pathways. Journal of Agriculture and Food Chemistry. 2017 Mar 1;65(8):1533-1542. Co-first author. 9.Yu J, Jiang Z, Ning L, Zhao Z, Yang N, Chen L, Ma H, Li L, Fu Y, Zhu H, Qi H. Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1. Biological and Pharmaceutical Bulletin. 2015;38(10):1564-72. 10. Dai W, Wang H, Ji H, Xiao X, Li Y, Jiang D, Luo Y, Xiao X, Yan B, Yu J*, Li L*. Nicking enzyme assisted amplification combined with CRISPR-Cas12a system for one-pot sensitive detection of APE1. Analyst. 2025 Mar 10. doi: 10.1039/d5an00009b. Epub ahead of print. 11.Jie Yu, Li-Da Du, Xiu-Ping Chen, Shou-Bao Wang, Guan-Hua Du, Cissampelini Methiodidum, Nature Small Molecule Drugs from Plants, PEOPLE’S MEDICAL PUBLISHING HOUSE, Springer, page 215-219; 12.Jie Yu, Bingling Zhong, Xiuping Chen, Induction of programmed necrosis by phytochemicals in colorectal cancer, Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Elsevier, page117-133. 13.余洁,陈修平,《傣肌松》,《天然小分子药物》,人民卫生出版社,page 141-143。 |
